Nanocrystallization of Rare Tolbutamide Form V in Mesoporous MCM-41 Silica
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Asymmetric Synthesis of Modafinil and its Derivatives by using the Functionalized Silica-based Mesoporous MCM-41
Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2018
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.8b00575